Predictive Models to Design and Develop New Antibiotics Derived from the Community for Open Antimicrobial Drug Discovery

设计和开发来自社区的新抗生素的预测模型，用于开放式抗菌药物发现

• 批准号: nhmrc : 2004356
• 金额: $ 97.74万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/predictive-models-design-drug-discovery/1780338
• 关键词: Predictive; Models; Design; Develop; New

With the rise of infections from multidrug-resistant bacteria, and limited antibiotics in the development pipeline, new strategies are required to generate novel antibiotics. This project will apply artificial intelligence methods to study a unique dataset generated over five years with the help of over 300 academic groups around the world. It will produce predictive models that will then be applied to design new antibiotics, which will be synthesized and tested for antimicrobial activity.

随着多重耐药细菌感染的增加，以及开发管道中有限的抗生素，需要新的策略来产生新的抗生素。该项目将应用人工智能方法来研究在全球300多个学术团体的帮助下在五年内生成的独特数据集。它将产生预测模型，然后应用于设计新的抗生素，这些抗生素将被合成并测试抗菌活性。