PRESENILINS IN ALZHEIMER'S DISEASE

早老素在阿尔茨海默病中的作用

• 批准号: nhmrc : 114132
• 负责人: Prof Colin Masters
• 金额: $ 13.98万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2001-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/presenilins-alzheimers-disease/77862
• 关键词: PRESENILINS; ALZHEIMER; DISEASE

The presenilin proteins are key components in the development of Alzheimer's disease. Mutations in these proteins can cause early Alzheimer's disease. We will continue our study of the biochemistry and cell biology of these proteins using tools and experimental models that we have already developed. This will provide important information on the mechanism of the disease process and give new leads in the treatment of the disease. The new technologies of genetic screening for presenilin mutations will be developed and utilized as a National referral base.

早老素蛋白是阿尔茨海默病发病过程中的关键成分。这些蛋白质的突变会导致早期阿尔茨海默病。我们将继续使用我们已经开发的工具和实验模型来研究这些蛋白质的生物化学和细胞生物学。这将为该病的发病机制提供重要信息，并为该病的治疗提供新的线索。将开发早老素突变的基因筛查新技术，并将其用作国家转诊基地。