PRESENILINS IN ALZHEIMER'S DISEASE

早老素蛋白是阿尔茨海默病发展的关键成分。这些蛋白质的突变可能导致早期阿尔茨海默病。我们将使用我们已经开发的工具和实验模型继续研究这些蛋白质的生物化学和细胞生物学。这将为疾病过程的机制提供重要信息，并为疾病的治疗提供新的线索。将开发早老素突变基因筛查的新技术，并将其用作国家参考基础。

The presenilin proteins are key components in the development of Alzheimer's disease. Mutations in these proteins can cause early Alzheimer's disease. We will continue our study of the biochemistry and cell biology of these proteins using tools and experimental models that we have already developed. This will provide important information on the mechanism of the disease process and give new leads in the treatment of the disease. The new technologies of genetic screening for presenilin mutations will be developed and utilized as a National referral base.