Enhancing Participation of Historically Minoritized Groups in Alzheimer Disease and Related Dementias Research

项目概要/摘要 题为“加强历史上少数群体参与阿尔茨海默病”的全国会议 疾病和相关痴呆症研究”，在本申请中提出的代表有意（但COVID 2018年全国研讨会的后续行动，“非裔美国人参与阿尔茨海默病 研究：有效的战略”，在华盛顿大学（WU）在圣路易斯举行，2018年10月10日。的 研讨会由R13 AG 059415（JC Morris，PI）资助，并由WU的Knight阿尔茨海默病主办 研究中心（ADRC）。2018年研讨会的观众包括来自国家的代表（例如， 美国国家老龄化研究所、阿尔茨海默氏症协会和非裔美国人阿尔茨海默氏症协会 网络）和圣路易斯社区（例如，非裔美国人咨询委员会的骑士ADRC，圣。 路易斯神职人员联盟和链接公司的圣路易斯分会）致力于 提高研究工作的多样性，以了解，可靠地诊断和有效地治疗阿尔茨海默病 和相关痴呆症（ADRD）。然而，主要的观众是每个NIA的领导层- 资助的ADRC，因为ADRC网络支持招募、登记、评估和 纵向跟踪，以提供ADRD科学研究所必需的数据和生物标本。 拟议的会议将于2023年10月12日至13日在圣路易斯的华盛顿大学举行， 解决发展成果中心继续缺乏协调战略以确保适当征聘的问题， 参与和保留来自历史上少数群体的研究参与者。有四 会议目标：1）使ADRC网络采用统一的定义、术语和语言， ADRD研究中的少数群体; 2）审查获得社会数据的新电池 导致ADRD种族和民族差异的健康决定因素; 3）鼓励ADRC 网络，以解决社区发起的研究课题;和4）有ADRC网络纳入一个 建立统一框架，加强少数群体人员的征聘、参与和留用 在ADRD研究中。迄今为止，已有6名主持人（2名妇女; 3名 黑人，1名亚洲人; 1名西班牙裔/拉丁裔）和22名讲者（15名女性; 8名黑人，3名亚洲人，1名美洲印第安人/阿拉斯加人 土著人; 2名西班牙裔/拉丁裔/x/a）。缔约方会议制定的有效战略将用于 ADRC网络，而且还向整个科学界传播。

Project Summary/Abstract The national Conference, entitled “Enhancing Participation of Historically Minoritized Groups in Alzheimer Disease and Related Dementias Research”, proposed in this application represents the intentional (but COVID pandemic-delayed) follow-up to the 2018 national Workshop, “African American Participation in Alzheimer Research: Effective Strategies”, held at Washington University (WU) in St. Louis on October 10th, 2018. The Workshop was funded by R13 AG059415 (JC Morris, PI) and was hosted by WU’s Knight Alzheimer Disease Research Center (ADRC). The audience for the 2018 Workshop included representatives from national (e.g., the National Institute on Aging, the Alzheimer’s Association, and the AfricanAmericansAgainstAlzheimer’s Network) and St. Louis community (e.g., the African American Advisory Board for the Knight ADRC, the St. Louis Clergy Coalition, and the St. Louis Chapter of the Links, Inc.) organizations that are committed to improving diversity in research efforts to understand, reliably diagnose, and effectively treat Alzheimer Disease and Related Dementias (ADRD). However, the primary audience was the leadership of each of the NIA- funded ADRCs as the ADRC network supports the clinical cohorts that are recruited, enrolled, assessed, and longitudinally followed to provide the data and biospecimens that are essential for scientific studies in ADRD. The proposed Conference will be held at Washington University in St. Louis on October 12-13, 2023, to address the continuing lack in the ADRCs of coordinated strategies to ensure the appropriate recruitment, engagement, and retention of research participants from historically minoritized populations. There are four Conference objectives: 1) to have the ADRC network adopt uniform definitions, terms, and language for use for minoritized populations in ADRD research; 2) to review new batteries that obtain data on the social determinants of health that contribute to racial and ethnic differences in ADRD; 3) to encourage the ADRC network to address community-initiated research topics; and 4) to have the ADRC network incorporate a uniform framework to enhance the recruitment, engagement, and retention of persons from minoritized groups in ADRD research. To date, the proposed Conference has acceptances from 6 Moderators (2 women; 3 Black, 1 Asian; 1 Hispanic/Latinx) and 22 speakers (15 women; 8 Black, 3 Asian, 1 American Indian/Alaska Native; 2 Hispanic/Latino/x/a). The effective strategies developed by the Conference will be used by the ADRC network but also disseminated to the scientific community at large.