Preventing myocardial infarction: A mouse model of atherosclerotic plaque instability/rupture as unique tool for establishing novel pharmacological strategies and targeted molecular imaging

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Myocardial infarction strikes without warning and thereby causes death or major disability. It is typically caused by sudden rupture of atherosclerotic plaques and occlusion of coronary arteries. Research on this was hampered by the lack of an animal model of plaque rupture. We have newly established a mouse model, which we will now use to generate novel tools to image and identify plaques that are prone to rupture and to develop novel therapies preventing plaque rupture and myocardial infarction.