Preventing myocardial infarction: A mouse model of atherosclerotic plaque instability/rupture as unique tool for establishing novel pharmacological strategies and targeted molecular imaging

预防心肌梗死：动脉粥样硬化斑块不稳定/破裂的小鼠模型作为建立新药理学策略和靶向分子成像的独特工具

• 批准号: nhmrc : 1003234
• 负责人: Prof Alexander Bobik
• 金额: $ 39.14万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/preventing-myocardial-infarction-molecular-imaging/108907
• 关键词: Preventing; myocardial; infarction; mouse; model

Myocardial infarction strikes without warning and thereby causes death or major disability. It is typically caused by sudden rupture of atherosclerotic plaques and occlusion of coronary arteries. Research on this was hampered by the lack of an animal model of plaque rupture. We have newly established a mouse model, which we will now use to generate novel tools to image and identify plaques that are prone to rupture and to develop novel therapies preventing plaque rupture and myocardial infarction.

心肌梗塞在没有征兆的情况下发作，从而导致死亡或严重残疾。它通常是由动脉粥样硬化斑块突然破裂和冠状动脉闭塞引起的。由于缺乏斑块破裂的动物模型，这方面的研究受到了阻碍。我们新建立了一个小鼠模型，现在我们将使用它来生成新的工具来成像和识别容易破裂的斑块，并开发预防斑块破裂和心肌梗死的新疗法。