Monomeric C-reactive protein as pathogenic factor and therapeutic target in atherothrombotic disease.

单体 C 反应蛋白作为动脉粥样硬化血栓性疾病的致病因子和治疗靶点。

• 批准号: nhmrc : 472666
• 负责人: Prof Alexander Bobik
• 金额: $ 45万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/monomeric-c-reactive-atherothrombotic-disease/99487
• 关键词: Monomeric; reactive; protein; pathogenic; factor

CRP is a plasma marker that can identify individuals at high risk for heart attack and stroke. Our preliminary data suggests that plasma CRP is not only an innocent marker, but can also be activated and thereby become a strong inflammatory stimulus by changing from a five unit to a single unit form on the surface of activated platelets. We will investigate this CRP activation in vitro, in animal models and in patients, and aim to develop new drug therapies for diseases such as heart attack.

CRP是一种血浆标志物，可以识别心脏病发作和中风的高风险个体。我们的初步数据表明，血浆CRP不仅是一个无辜的标志物，但也可以被激活，从而成为一个强大的炎症刺激，从一个五个单位的形式变成一个单位的活化血小板表面。我们将在体外，动物模型和患者中研究这种CRP激活，并旨在开发新的药物治疗心脏病等疾病。