Monomeric C-reactive protein as pathogenic factor and therapeutic target in atherothrombotic disease.

CRP是一种血浆标志物，可以识别心脏病发作和中风的高危个体。我们的初步数据表明，血浆CRP不仅是一个无害的标志物，而且还可以被激活，从而通过在激活的血小板表面从五个单位变成一个单一单位而成为一种强烈的炎症刺激。我们将在体外、动物模型和患者中研究这种CRP的激活，并旨在开发治疗心脏病等疾病的新药物疗法。

CRP is a plasma marker that can identify individuals at high risk for heart attack and stroke. Our preliminary data suggests that plasma CRP is not only an innocent marker, but can also be activated and thereby become a strong inflammatory stimulus by changing from a five unit to a single unit form on the surface of activated platelets. We will investigate this CRP activation in vitro, in animal models and in patients, and aim to develop new drug therapies for diseases such as heart attack.