Prevention of HIV-1 infection by adeno associated virus vector-delivered broadly neutralizing antibodies or antibody-like molecules

通过腺相关病毒载体传递的广泛中和抗体或抗体样分子预防 HIV-1 感染

• 批准号: nhmrc : 1124680
• 金额: $ 60.03万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/prevention-hiv-1-like-molecules/947410
• 关键词: Prevention; HIV; infection; adeno; associated

A promising neutralizing molecule has boosted hopes of an HIV vaccine. It remains unknown how well this molecule prevents HIV infection under conditions reflecting “real world” exposure, including exposure to HIV in the form of cells carrying virus or free-floating virus in the presence of semen. We will assess this molecule for their ability to inhibit transmission of HIV-like viruses under these conditions. These experiments will define requirements to protect against HIV infection.

一种有希望的中和分子提高了艾滋病毒疫苗的希望。在反映“真实的世界”暴露的条件下，包括暴露于携带病毒的细胞或精液中存在的自由漂浮病毒形式的艾滋病毒，这种分子预防艾滋病毒感染的效果如何仍然未知。我们将评估这种分子在这些条件下抑制HIV样病毒传播的能力。这些实验将确定防止艾滋病毒感染的要求。