Probing changes in G protein-coupled receptor signalling networks during breast cancer progression

探究乳腺癌进展过程中 G 蛋白偶联受体信号网络的变化

• 批准号: nhmrc : 2004126
• 金额: $ 89.27万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/probing-changes-g-cancer-progression/1780293
• 关键词: Probing; changes; protein; coupled; receptor

The b2-adrenoceptor is a protein receptor that enables cells to respond to hormones. In breast cancer, this receptor causes more aggressive tumour cells to metastasise faster in response to stress. This proposal aims to understand why this response occurs in only very aggressive cells, and to identify how we can better target blocking drugs to this receptor. This could allow us to design better drugs with fewer side effects.

b2肾上腺素受体是一种蛋白质受体，它能使细胞对激素产生反应。在乳腺癌中，这种受体会导致更具侵略性的肿瘤细胞在压力下更快地转移。该提案旨在了解为什么这种反应只发生在非常具有攻击性的细胞中，并确定我们如何更好地将阻断药物靶向这种受体。这可以让我们设计出副作用更少的更好的药物。