Signal Processing Along the Auditory Pathway: Changes Following Noise Exposure

沿着听觉通路的信号处理：噪声暴露后的变化

• 批准号: 10536262
• 负责人: Wei Dong
• 金额: --
• 依托单位: VA LOMA LINDA HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10536262
• 关键词: Affect; American; Animals; Apical; Auditory; Auditory Threshold; Auditory system; Back; Brain; Calibration; Cessation of life; Clinic; Clinical; Cochlea; Complex; Coupling; Diagnosis; Diagnostic; Diagnostic tests; Differential Diagnosis; Ear; Elements; Environment; External auditory canal; Foundations; Frequencies; Gerbils; Goals; Hair Cells; Health; Hearing; Hearing Tests; Human; Impairment; Individual; Injury; Intervention; Knowledge; Labyrinth; Link; Loudness; Maps; Measurement; Measures; Mechanics; Medical; Military Personnel; Modeling; Monitor; Motion; Nervous System; Neurons; Noise; Optical Coherence Tomography; Outer Hair Cells; Physiological; Population; Rehabilitation therapy; Research; Sensorineural Hearing Loss; Sensory; Services; Signal Transduction; Speech; Speech Perception; Structure; Structure-Activity Relationship; System; Techniques; Testing; Time; Translating; Traumatic Brain Injury; Veterans; Work; auditory pathway; blast exposure; cell injury; clinical application; clinical diagnosis; design; diagnostic tool; experimental study; hearing impairment; improved; individual response; neural; neural hearing loss; noise exposure; normal hearing; notch protein; novel; otoacoustic emission; personalized diagnostics; rehabilitation strategy; response; signal processing; sound

Project Summary/Abstract Sensorineural hearing loss (SNHL) in military personnel is commonly caused by noise- or blast-related damage to the auditory periphery (cochlea) and/or the central system, which includes changes in the integrity of the cochlear partition and cellular death along the auditory pathway. Hearing loss is often permanent, and there exist no cures for sustained injuries. The current proposal seeks to characterize the signal processing along the auditory pathway by establishing the structure-function relationship in both normal ears and with various types of SNHL. The overall goal is to improve the diagnosis of SNHL within the clinic by separating contributions from cochlear (sensory) and retro-cochlear (neural) loss. We will combine a novel, state-of-the-art measurement technique (optical coherence tomography, OCT) with recordings that are already available in the clinic [i.e., distortion product otoacoustic emissions (DPOAE) in the ear canal and frequency-following responses (FFR) from the cortex] so that the cochlear mechanics and the detrimental effects of noise- or blast- exposure can be evaluated at different stages along the auditory pathway. As of now, OCT measures from the cochlea cannot be recorded from humans, but we expect that the combination of DPOAE and FFR provides a differential diagnosis of SNHL that distinguishes damage of the sensory versus neural component. Aim 1 of this proposal will form the foundation of the study by determining how DPOAEs and FFRs relate to cochlear micromechanics in normal gerbil ears. The experimental results will be used to develop a Best Approximation Model (BAM) that will predict cochlear function using DPOAEs and FFRs. In Aim 2 we will explore how various forms of SNHL change the underlying cochlear mechanics with the specific design to differentially diagnose sensory and neural hearing loss and establish how these changes can be quantified using a combination of DPOAE and FFR measurements. These results will further validate the BAM developed under Aim 1. In Aim 3 we will apply the knowledge obtained in animals to humans that suffer from different types of SNHL to improve the clinical differential diagnosis of an SNHL using DPOAEs, FFRs, and the BAM. Using direct and simultaneous measurements along the auditory pathway, the signal processing under these conditions will be quantified in detail. The proposed research will advance our understanding of sound processing within the auditory system, especially at low frequencies that are important for speech and provide critical information to improve our ability to diagnose and develop new treatments for SNHL. This will benefit our Veterans, many of whom suffer from noise/blast-induced hearing loss.

项目摘要/摘要 军事人员中的感官听力损失（SNHL）通常是由噪音或爆炸有关的 损坏听觉外围（耳蜗）和/或中央系统，其中包括完整性的变化 沿听觉途径的耳蜗分区和细胞死亡。听力损失通常是永久的，并且 没有持续伤害的治疗方法。当前的提案旨在表征信号处理 沿着听觉途径通过在正常耳朵和与 各种类型的SNHL。总体目标是通过分开来改善诊所内SNHL的诊断 人工耳蜗（感觉）和恢复（神经）损失的贡献。我们将结合一部小说，最先进的 测量技术（光学相干断层扫描，OCT），其录音已在 诊所[即，耳道和频率跟随频率的失真产物耳声排放（DPOAE） 来自皮质的反应（FFR）]，因此，人工耳蜗和噪声或爆炸的有害影响 可以在听觉途径的不同阶段评估曝光。截至目前，OCT从 无法从人类记录耳蜗，但我们期望DPOAE和FFR的组合提供 SNHL的差异诊断，可区分感觉与神经成分的损害。目标1 该建议将通过确定DPOAE和FFR与人工耳蜗的关系来构成研究的基础 正常的沙鼠耳朵中的微力学。实验结果将用于开发最佳近似 模型（BAM）将使用DPOAE和FFR预测耳蜗函数。在AIM 2中，我们将探索各种各样的 SNHL的形式改变了基础的人工耳蜗机制，具体设计差异诊断 感觉和神经听力损失，并确定如何使用组合来量化这些变化 DPOAE和FFR测量。这些结果将进一步验证AIM 1下开发的BAM。在AIM 3中 我们将把动物获得的知识应用于患有不同类型SNHL的人类以改进的人类 使用DPOAE，FFR和BAM对SNHL的临床差异诊断。使用直接和 同时沿听觉途径进行测量，在这些条件下的信号处理将是 详细量化。拟议的研究将提高我们对内部合理处理的理解 听觉系统，尤其是在对语音很重要的低频中，并提供关键信息 提高我们诊断和开发SNHL新治疗方法的能力。这将使我们的退伍军人，许多 患有噪音/爆炸引起的听力损失的人。