Progression of influenza virus within the respiratory tract

流感病毒在呼吸道内的进展

• 批准号: nhmrc : 509281
• 负责人: Dr Deborah Middleton
• 金额: $ 34.25万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/progression-influenza-virus-respiratory-tract/82891
• 关键词: Progression; influenza; virus; within; respiratory

We are exploring how influenza virus moves down the respiratory tract after infecting the nose. We have identified a component of mouse saliva that can halt the progression from the nose to the trachea and lungs and will determine how it binds to the virus to stop infection. We will also examine how human and highly lethal avian viruses move from the upper respiratory tract to other organs in the mouse and also in the ferret, which is a much better model for mimicking what happens in man.

我们正在探索流感病毒如何在感染鼻子后沿呼吸道移动。我们已经确定了小鼠唾液中的一种成分，它可以阻止从鼻子到气管和肺部的进展，并将确定它如何与病毒结合以阻止感染。我们还将研究人类和高致命性禽流感病毒如何从小鼠和雪貂的上呼吸道转移到其他器官，雪貂是模拟人类发生的情况的更好模型。