Influenza A virus PB1-F2 protein: a putative virulence factor and initiator of inflammation

甲型流感病毒 PB1-F2 蛋白：假定的毒力因子和炎症引发剂

• 批准号: nhmrc : 1026619
• 负责人: Dr Deborah Middleton
• 金额: $ 31.65万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/influenza-virus-pb1-initiator-inflammation/110510
• 关键词: Influenza; virus; PB1; F2; protein

Influenza virus produces a protein of undefined function called PB1-F2. Infection of mice with virus expressing PB1-F2 from virulent strains causes severe lung inflammation, while PB1-F2 from milder seasonal viruses does not. We will examine how PB1-F2 influences virulence of human influenza in the ferret, which exhibits the same illness as humans. This work will help understand the disease severity of newly evolved influenza viruses of humans and the role of PB1-F2 in mediating this.

流感病毒产生一种功能不明的蛋白质，称为PB1-F2。来自强毒株的表达PB1-F2的病毒感染小鼠会引起严重的肺部炎症，而来自较温和的季节性病毒的PB1-F2不会引起严重的肺部炎症。我们将研究PB1-F2如何影响雪貂体内人类流感的毒力，雪貂表现出与人类相同的疾病。这项工作将有助于了解人类新进化的流感病毒的疾病严重性以及PB1-F2在其中的作用。