Protecting the efficacy of antimalarial therapies with novel approaches to suppress the emergence of drug resistance

通过抑制耐药性出现的新方法来保护抗疟疗法的功效

• 批准号: nhmrc : 1120690
• 金额: $ 27.79万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/protecting-efficacy-antimalarial-drug-resistance/946609
• 关键词: Protecting; efficacy; antimalarial; therapies; novel

The global campaign to eliminate malaria is under serious threat from the continuing emergence and spread of Plasmodium falciparum parasites resistant to antimalarial drugs. However in acquiring resistance to one drug, the parasite can become more susceptible to other antimalarials. This project aims to 1) test the ability of drug pairs with opposing selection forces to suppress resistance in vitro and 2) define the physiological and molecular basis of these opposing evolutionary forces.

全球消灭疟疾运动受到对抗疟药物具有抗药性的恶性疟原虫持续出现和传播的严重威胁。然而，在获得对一种药物的耐药性后，寄生虫可能变得更容易受到其他抗疟药的影响。本项目旨在1)测试具有相反选择力的药物对在体外抑制耐药性的能力，2)确定这些相反进化力的生理和分子基础。