Protecting the efficacy of antimalarial therapies with novel approaches to suppress the emergence of drug resistance

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The global campaign to eliminate malaria is under serious threat from the continuing emergence and spread of Plasmodium falciparum parasites resistant to antimalarial drugs. However in acquiring resistance to one drug, the parasite can become more susceptible to other antimalarials. This project aims to 1) test the ability of drug pairs with opposing selection forces to suppress resistance in vitro and 2) define the physiological and molecular basis of these opposing evolutionary forces.