Geo-enabled detect and respond system for antimalarial resistance in Ghana: GDRS - Ghana

加纳的抗疟药耐药性地理检测和响应系统：GDRS - 加纳

• 批准号: 10713339
• 负责人: Alash'le G. Abimiku
• 金额: --
• 依托单位: AKROS RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-11 至 2024-02-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10713339
• 关键词: Africa; African; Anti-malarial drug resistance; Antimalarials; Area; Blood; Cellular biology; Collaborations; Communities; Containment; Data; Data Science; Decision Making; Dryness; Early Diagnosis; Epidemiology; Field Workers; Genetic; Genomics; Geography; Ghana; HIV; Household; Human; Intervention; Investigation; Laboratories; Laboratory Research; Link; Malaria; Modeling; Molecular; Monitor; Nigeria; Patients; Pattern; Pharmaceutical Preparations; Plasmodium; Research; Research Personnel; Resistance; Sampling; Spottings; Strategic Planning; System; Translating; Treatment Failure; Vaccines; Visualization; Work; coronavirus disease; data streams; design; drug efficacy; epidemiologic data; genomic data; improved; innovation; insight; member; molecular marker; next generation sequencing; open source; pathogen; programs; research study; response; sociodemographics; spatiotemporal; surveillance data; surveillance network; tool; treatment guidelines; virology

Project summary Antimalarial drug resistance is a continuing challenge in the global effort to control and eliminate malaria. Well designed, rapid and highly granular antimalarial surveillance systems are urgently needed to protect the efficacy of remaining antimalarial treatments and inform discovery of new, effective drugs and vaccines. Molecular markers are useful tools to monitor anti-malarial drug resistance and, if used in routine surveillance, could help to detect and monitor the early emergence of resistance before it translates to treatment failures. This project will address the need for more powerful molecular surveillance through a strategic collaboration between two geographically and scientifically complementary, Africa-based networks - the DS-I Africa INFORM Research Hub and the West African Center for Cell Biology for Infectious Pathogens (WACCBIP). Akros and the Institute for Human Virology Nigeria, both part of the INFORM Research hub, will collaborate with WACCBIP to strengthen Ghana’s malaria genomic surveillance network to include capture of community-level, geo enabled dried blood spot (DBS) samples and expand this network to include additional epidemiologic and genomic data streams across geographies in Africa. This partnership will leverage WACCBIP’s existing genomic surveillance ‘hub-and-spoke’ lab network and integrate the network with the work of the DS-I Africa INFORM Research hub. The deliberate, strategic plan to integrate WACCBIP with partners within DS-I Africa will expand geographic coverage of geospatial surveillance through pivoting the open-source ‘Reveal’ geospatial platform already in use by DS-I Africa. With the use of Reveal, the consortium will geoenable WACCBIP’s existing malaria genomic surveillance network and expand the platform to link DBS data collected at the household level to advanced next generation sequencing (NGS) labs. Through this project, stakeholders will be equipped to visualize and monitor molecular markers of antimalarial resistance captured from the DBS samples, and geospatially align these genomic data to other data streams including epidemiologic, programmatic, and socio-demographic data to inform intervention response. The linking and geoenabling of the existing surveillance network to the Reveal platform will increase granular geospatial and temporal antimalarial resistance insights to guide responsive action and drive epidemiological understanding of antimalarial resistance emergence and spread. We envision this project will provide a model for a) geoenabled community-level genomic surveillance, b) better understanding of the manifestation of antimalarial resistance at a granular level, and c) timely access to critical evidence to guide national decision-making for malaria program response and adaptation.

项目摘要 在全球控制和消除疟疾方面的努力中，抗疟药耐药性是一个持续的挑战。设计精良， 迫切需要快速且高度颗粒状的抗疟疾监测系统来保护剩余的效率 抗疟疾治疗并为发现新的有效药物和疫苗的发现提供信息。分子标记是有用的工具 监测抗疟疾耐药性，如果用于常规监视，则可以帮助检测和监测早期 抵抗的出现在转化为治疗失败之前。 该项目将通过战略合作之间的需要解决更强大的分子监视的需求 两个地理和科学完整的基于非洲的网络 - DS-I非洲为研究中心提供信息 以及西非传染病细胞生物学中心（WACCBIP）。阿克罗斯和人类研究所 尼日利亚病毒学是Inform Research Hub的一部分，将与Waccbip合作，以增强加纳的疟疾 基因组监视网络包括捕获社区级，启用GEO的干血点（DBS）样本和 扩展该网络，包括非洲地理位置各个地理位置的其他流行病学和基因组数据流。这 合作伙伴关系将利用Waccbip现有的基因组监视“ Hub and Skoke”实验室网络并整合网络 DS-I非洲的工作信息。 将WACCBIP与DS-I非洲内部合作伙伴整合到的故意，战略计划将扩大地理覆盖范围 DS-I Africa已经使用的开源“揭示”地理空间平台通过旋转地理空间监视。 随着揭露的使用，该财团将使Waccbip现有的疟疾基因组监测网络和 将平台扩展到将家庭级别收集的DBS数据链接到高级下一代测序（NGS）实验室。 通过这个项目，利益相关者将等同于可视化和监视抗疟疾的分子标记 从DBS样品中捕获，并将这些基因组数据与其他数据流相一致，包括流行病学， 程序化和社会人口统计数据，以告知干预响应。现有的链接和地理位置 揭示平台的监视网络将增加颗粒状地理空间和临时抗疟疾阻力 引导响应式行动并推动对抗疟疾抗药性出现和流行病学理解的见解 传播。 我们设想该项目将为a）a）地理位置社区级基因组监视，b）更好 理解粒状层面抗疟疾抗性的表现，c）及时获得关键证据 指导国家决策以进行疟疾计划的反应和适应。