Altering macrophage phenotype for the treatment of chronic airway disease and lung cancer

改变巨噬细胞表型以治疗慢性气道疾病和肺癌

• 批准号: nhmrc : 1081373
• 负责人: A/Pr Steven Bozinovski
• 金额: $ 60.32万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/altering-macrophage-phenotype-lung-cancer/518806
• 关键词: Altering; macrophage; phenotype; treatment; chronic

The aim of this proposal is to identify mechanisms through which the Src family kinase Hck promotes innate immune cell-dependent, chronic lung inflammation and lung cancer development. Our preliminary data suggest that excessive Hck activity provides a molecular mechanism to skew macrophage polarization towards an alternatively activated, M2-like phenotype associated with chronic airways disease, and the tumour promoting microenvironment.

这项建议的目的是确定Src家族激酶HCK促进先天性免疫细胞依赖、慢性肺部炎症和肺癌发生的机制。我们的初步数据表明，过度的HCK活性提供了一种分子机制，使巨噬细胞极化偏向与慢性呼吸道疾病和促进肿瘤的微环境相关的交替激活的M2样表型。