Cigaratte smoke exposure suppresses alveolar macrophage responses to lipopolysaccharide by modifying the TLR4 pathway

香烟烟雾暴露通过改变 TLR4 通路抑制肺泡巨噬细胞对脂多糖的反应

• 批准号: nhmrc : 509226
• 负责人: A/Pr Steven Bozinovski
• 金额: $ 33.76万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cigaratte-smoke-exposure-tlr4-pathway/82111
• 关键词: Cigaratte; smoke; exposure; suppresses; alveolar

Long term cigarette smoke exposure is a major risk factor for cancer, heart disease and emphysema. A less known fact about smoke exposure is that it also leaves people susceptible to respiratory infections by i) physically damaging the lung lining and ii) suppressing cells responsible for coordinating the lungs defence system. This project will identify how smoke exposure blocks the early response to infection by the immune system and discovery novel ways of restoring normal lung defences.

长期接触香烟烟雾是癌症、心脏病和肺气肿的主要危险因素。关于烟雾暴露的一个鲜为人知的事实是，它也使人们容易受到呼吸道感染，因为i）物理损伤肺衬里，ii）抑制负责协调肺部防御系统的细胞。该项目将确定烟雾暴露如何阻止免疫系统对感染的早期反应，并发现恢复正常肺部防御的新方法。