Alternate Splicing of tryptase genes regulates their specificity
Alternate Splicing of tryptase genes regulates their specificity
批准号:
nhmrc : 630660
负责人:
Dr John Hunt
金额:
$19.62万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2014-12-31
中文摘要
类胰蛋白酶是一种与关节炎、炎症性肠病(IBD)和哮喘等炎症性疾病有关的酶。特定的类胰蛋白酶抑制剂在治疗这些疾病方面是有效的。我们已经发现,每个人类类胰蛋白酶基因通过一种称为交替剪接的机制被加工成两种不同的蛋白质产物。我们将研究这些细胞的结构和功能。
英文摘要
Tryptases are enzymes implicated in inflammatory disorders including arthritis, inflammatory bowel disease (IBD) and asthma. Specific tryptase inhibitors are effective in treating these diseases. We have discovered that each human tryptase gene is processed into two different protein products via a mechanism called alternate splicing. We will investigate the structure and function of these.
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会议论文
Mechanisms of inflammation by S100A12
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批准号:nhmrc : 157067
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项目类别:NHMRC Project Grants
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资助金额:$26.14万
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财政年份:2001
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负责人:Dr John Hunt
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依托单位:
Cloning, characterisation, and expression of the human mast cell tryptase family.
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批准号:nhmrc : 990262
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项目类别:NHMRC Project Grants
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资助金额:$24.63万
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财政年份:1999
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负责人:Dr John Hunt
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依托单位:
海外基金