Alternative splicing- a regulatory mechanism determining self-renewal and pluripotency of ES and iPS cells

选择性剪接——决定 ES 和 iPS 细胞自我更新和多能性的调节机制

• 批准号: nhmrc : 1043092
• 负责人: Dr Minna-Liisa Anko
• 金额: $ 44.32万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/alternative-splicing-regulatory-ips-cells/111542
• 关键词: Alternative; splicing; regulatory; mechanism; determining

Stem cells hold great promise in cell replacement therapies and may provide models to study human diseases and to screen new pharmaceuticals. For successful future therapeutic applications, a deeper understanding of the molecular mechanisms governing the behavior of stem cells is crucial. In this proposal we will investigate the role of alternative splicing in the control of the fundamental properties of stem cells, and identify target RNAs and gene expression networks regulated by splicing factors.

干细胞在细胞替代疗法中具有很大的前景，并可能为研究人类疾病和筛选新药提供模型。对于未来成功的治疗应用，更深入地了解控制干细胞行为的分子机制是至关重要的。在本研究中，我们将研究选择性剪接在控制干细胞基本特性中的作用，并确定剪接因子调控的靶rna和基因表达网络。