Alveolar macrophage zinc and zinc transporters and their role in phagocytosis

肺泡巨噬细胞锌和锌转运蛋白及其在吞噬作用中的作用

• 批准号: nhmrc : 627223
• 负责人: Dr Peter Zalewski
• 金额: $ 19.27万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/alveolar-macrophage-zinc-role-phagocytosis/80911
• 关键词: Alveolar; macrophage; zinc; transporters; their

Zinc is an essential dietary component that serves a number of functions in the lungs. It is both an anti-oxidant and anti-inflammatory agent. Some airway inflammatory diseases such as emphysema may involve a critical loss of lung zinc. We believe that cigarette smoke causes the loss of zinc and this prevents the lung macrophages from working properly to clear bacteria and dead cells. This will provide a foundation for our long term goals of better clinical management of emphysema.

锌是一种重要的膳食成分，对肺部有多种功能。它既是抗氧化剂又是抗炎剂。一些气道炎症性疾病，如肺气肿可能涉及肺锌的严重损失。我们认为，吸烟会导致锌的流失，从而阻止肺巨噬细胞正常工作，清除细菌和死细胞。这将为我们更好地临床管理肺气肿的长期目标奠定基础。