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Exploiting increased autophagy in bronchial epithelial cells: a new therapeutic approach for chronic obstructive pulmonary disease (COPD)

Exploiting increased autophagy in bronchial epithelial cells: a new therapeutic approach for chronic obstructive pulmonary disease (COPD)
利用支气管上皮细胞自噬的增加:慢性阻塞性肺疾病(COPD)的新治疗方法
批准号:
nhmrc : 1099040
负责人:
Dr Peter Zalewski
金额:
$49.7万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 2018-12-31

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中文摘要
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英文摘要
COPD is incurable, a leading cause of death, and new therapies are urgently needed. Autophagy is a cell response to cell stress conditions, however increased autophagy is harmful. We will investigate the association of increased autophagy with COPD and smoking and evaluate therapies that can reduce autophagy, including zinc-related drugs and novel antibiotics that have been modified to lose their anti-bacterial activity.
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会议论文
Alveolar macrophage zinc and zinc transporters and their role in phagocytosis
  • 批准号:
    nhmrc : 627223
  • 项目类别:
    NHMRC Project Grants
  • 资助金额:
    $19.27万
  • 财政年份:
    2010
  • 负责人:
    Dr Peter Zalewski
  • 依托单位:
Role of zinc in the respiratory epithelium and asthma
  • 批准号:
    nhmrc : 299005
  • 项目类别:
    NHMRC Project Grants
  • 资助金额:
    $14.95万
  • 财政年份:
    2004
  • 负责人:
    Dr Peter Zalewski
  • 依托单位:
海外基金