Exploiting increased autophagy in bronchial epithelial cells: a new therapeutic approach for chronic obstructive pulmonary disease (COPD)

利用支气管上皮细胞自噬的增加：慢性阻塞性肺疾病（COPD）的新治疗方法

• 批准号: nhmrc : 1099040
• 负责人: Dr Peter Zalewski
• 金额: $ 49.7万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/exploiting-increased-autophagy-disease-copd/662417
• 关键词: Exploiting; increased; autophagy; bronchial; epithelial

COPD is incurable, a leading cause of death, and new therapies are urgently needed. Autophagy is a cell response to cell stress conditions, however increased autophagy is harmful. We will investigate the association of increased autophagy with COPD and smoking and evaluate therapies that can reduce autophagy, including zinc-related drugs and novel antibiotics that have been modified to lose their anti-bacterial activity.

COPD是无法治愈的，是导致死亡的主要原因，迫切需要新的治疗方法。自噬是细胞对细胞应激条件的反应，然而增加的自噬是有害的。我们将研究自噬增加与COPD和吸烟的相关性，并评估可以减少自噬的疗法，包括锌相关药物和经过修饰失去抗菌活性的新型抗生素。