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An AMPK myristoyl switch controls AMP mediated metabolic stress signaling

An AMPK myristoyl switch controls AMP mediated metabolic stress signaling
AMPK 肉豆蔻酰开关控制 AMP 介导的代谢应激信号
批准号：
nhmrc : 1006062
负责人：
Dr Jon Oakhill
金额：
$35.0万
依托单位：
St. Vincent's Institute of Medical Research
依托单位国家：
澳大利亚
项目类别：
NHMRC Project Grants
财政年份：
2011
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2011-01-01 至 2013-12-31
来源：
https://researchdata.edu.au/an-ampk-myristoyl-stress-signaling/109144
关键词：
AMPKmyristoylswitchcontrolsAMP

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中文摘要
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英文摘要
This project is investigating an enzyme called AMP-activated protein kinase that plays a pivotal role in controlling how our bodies regulate energy metabolism in response to exercise and diet. Improved understanding of how this enzyme is regulated may provide new therapeutic methods for mimicking the beneficial effects of diet and exercise to treat multiple metabolic diseases including obesity, Type 2 diabetes and cardiovascular disease.
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Targeted development of AMPK ?2-isoform allosteric activators
? subunit function in the regulation of AMPK
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