An AMPK myristoyl switch controls AMP mediated metabolic stress signaling

AMPK 肉豆蔻酰开关控制 AMP 介导的代谢应激信号

• 批准号: nhmrc : 1006062
• 负责人: Dr Jon Oakhill
• 金额: $ 35万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/an-ampk-myristoyl-stress-signaling/109144
• 关键词: AMPK; myristoyl; switch; controls; AMP

This project is investigating an enzyme called AMP-activated protein kinase that plays a pivotal role in controlling how our bodies regulate energy metabolism in response to exercise and diet. Improved understanding of how this enzyme is regulated may provide new therapeutic methods for mimicking the beneficial effects of diet and exercise to treat multiple metabolic diseases including obesity, Type 2 diabetes and cardiovascular disease.

该项目正在研究一种称为AMP活化蛋白激酶的酶，这种酶在控制我们的身体如何调节能量代谢以应对运动和饮食方面起着关键作用。对这种酶如何调节的更好理解可能提供新的治疗方法，用于模拟饮食和运动的有益作用，以治疗多种代谢疾病，包括肥胖症，2型糖尿病和心血管疾病。