? subunit function in the regulation of AMPK

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• 批准号: nhmrc : 1068798
• 负责人: Dr Jon Oakhill
• 金额: $ 35.38万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/subunit-function-regulation-ampk/455359
• 关键词: subunit; function; regulation; AMPK

Many of the most serious diseases of Western societies including obesity, Type 2 diabetes, cancer growth and metastasis and cardiovascular disease have metabolic dimensions. The enzyme AMPK regulates cellular and whole body energy homeostasis by coordinating metabolic pathways to balance energy demand with nutrient supply. We are studying the structure and function of AMPK with the aim of better treating metabolic diseases.

西方社会中许多最严重的疾病，包括肥胖、2型糖尿病、癌症生长和转移以及心血管疾病，都有代谢方面的因素。AMPK酶通过协调代谢途径来平衡能量需求和营养供应，从而调节细胞和全身的能量动态平衡。我们正在研究AMPK的结构和功能，以期更好地治疗代谢性疾病。