An apotope of Ro60 in lupus

狼疮中 Ro60 的突变体

• 批准号: nhmrc : 595907
• 负责人: Prof David Gordon
• 金额: $ 35.99万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/an-apotope-ro60-lupus/81547
• 关键词: apotope; Ro60; lupus

This project introduces a new biomarker in systemic lupus erythematosus termed an apotope. The aims are to study the diagnostic potential of an apotope of Ro60, a key target in lupus, together with its ability to initiate the disease and cause organ damage. The interaction of the Ro60 apotope with a novel protective factor called beta2-glycoprotein I will also be studied. These discoveries are likely to lead to new diagnostic tests and preventions for lupus and neonatal lupus.

本项目介绍了一个新的生物标志物在系统性红斑狼疮称为apotope。目的是研究红斑狼疮的关键靶点Ro60的一个载子的诊断潜力，以及它引发疾病和导致器官损伤的能力。还将研究Ro60 apotope与一种称为β -糖蛋白I的新型保护因子的相互作用。这些发现可能会导致新的诊断测试和预防狼疮和新生儿狼疮。