The ecological dynamics of secreted bacteriocins and the evolution of multiple bacteriocin production in Escherichia coli

大肠杆菌分泌细菌素的生态动力学和多种细菌素生产的进化

• 批准号: DP0664453
• 负责人: Prof David Gordon
• 金额: $ 17.94万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0664453
• 关键词: ecological; dynamics; secreted; bacteriocins; evolution

Bacteria produce compounds known as bacteriocins that are toxic to other microorganisms. The success of bacteria as bio-control agents and in probiotic formulations for the control microbial pathogens is, in part, due to bacteriocins. Bacteriocins may also have a role as replacements for traditional antibiotics and as natural food preservatives. The potential usefulness of bacteriocins as the active agent in bio-control agents, as antibiotic replacements, as food preservatives, and as part of the repertoire of traits in probiotic formulations requires a sound understanding of the eco-evolutionary dynamics of bacteriocins. Understanding the ecology and evolution of bacteriocins is the goal of the proposed research.

细菌产生一种称为细菌素的化合物，对其他微生物有毒。细菌作为生物防治剂和用于控制微生物病原体的益生菌制剂的成功部分归功于细菌素。细菌素还可以作为传统抗生素的替代品和天然食品防腐剂。细菌素作为生物防治剂中的活性剂、抗生素替代品、食品防腐剂以及作为益生菌制剂特性库的一部分的潜在用途需要对细菌素的生态进化动力学有充分的了解。了解细菌素的生态和进化是本研究的目标。