Rational Co-targeting of G protein-coupled receptors as a novel approach towards treating neuropsychiatric disorders

G 蛋白偶联受体的合理共靶向作为治疗神经精神疾病的新方法

• 批准号: nhmrc : 1049564
• 负责人: Dr Ben Capuano
• 金额: $ 41.37万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/rational-co-targeting-neuropsychiatric-disorders/112094
• 关键词: Rational; Co; targeting; protein; coupled

Schizophrenia is a common mental disorder with multiple symptoms. Current therapeutics only treat some of these symptoms. This project will focus on two important brain proteins implicated in schizophrenia. With the hypothesis that the rational targeting of these two proteins will lead to the design of more effective medicines for treatment of schizophrenia we will develop novel methods to selectively and simultaneously and target these two proteins.

精神分裂症是一种常见的精神障碍，具有多种症状。目前的疗法只能治疗其中一些症状。该项目将重点关注与精神分裂症有关的两种重要的大脑蛋白质。假设合理靶向这两种蛋白质将导致设计出更有效的治疗精神分裂症的药物，我们将开发新的方法来选择性地同时靶向这两种蛋白质。