Towards the rational design of calcium sensing receptor allosteric modulators for the treatment of osteoporosis and calcium handling disorders

合理设计用于治疗骨质疏松症和钙处理障碍的钙传感受体变构调节剂

• 批准号: nhmrc : 1138891
• 负责人: Dr Ben Capuano
• 金额: $ 50.13万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/rational-design-calcium-handling-disorders/1318882
• 关键词: Towards; rational; design; calcium; sensing

Drugs that target the human calcium sensing receptor can be too strong or too weak, resulting in side effects or lack of efficacy. This proposal thus seeks to establish whether the strength of drug activity can be rationally altered and exploited to treat different disease states by fine-tuning CaSR activity in a disease-specific manner.

靶向人类钙敏感受体的药物可能太强或太弱，导致副作用或缺乏疗效。因此，该提案旨在确定药物活性的强度是否可以合理地改变并通过以疾病特异性方式微调CaSR活性来治疗不同的疾病状态。