Reactivities of CD8 T cells to mutated neo-antigens in lung malignancies

肿瘤表达突变的蛋白质(称为“新抗原”)，可以成为强大的杀手T细胞的靶标，从而摧毁癌细胞。为了了解为什么这些细胞不能治愈大多数癌症，我们将研究现代DNA测序方法识别的新抗原，以确定这些新抗原&对它们的反应。然后，将有可能在个别患者身上设计试验，例如个性化疫苗，以“迫使”免疫系统攻击携带这些新抗原的细胞。

Tumours express mutated proteins (called ‘neo-antigens’) which can be targets of powerful killer T cells which can destroy cancer cells. To understand why these cells fail to cure most cancers we will study neo-antigens identified by modern DNA sequencing methods to identify these neo-antigens & the responses to them. Then it will be possible to design trials in individual patients, e.g. personalised vaccines to ‘force’ the immune system to attack cells bearing these neo-antigens.