The impact of therapy on T-cell recognition of mutated tumour neo-antigens

治疗对 T 细胞识别突变肿瘤新抗原的影响

• 批准号: nhmrc : 1146909
• 负责人: A/Pr Mark Watson
• 金额: $ 75.13万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/impact-therapy-t-neo-antigens/1320760
• 关键词: impact; therapy; cell; recognition; mutated

Cancer is caused by mutations which should be 'seen' and destroyed by the patients immune cells, similar to how immune cells protect us against viruses. But they don't. This grant will study how current cancer treatments help the immune cells 'see' these mutations. We will undertake these studies in the important cancers lung cancer and mesothelioma.

癌症是由突变引起的，这些突变应该被患者的免疫细胞“看到”并摧毁，类似于免疫细胞如何保护我们免受病毒的侵害。但他们没有。这项拨款将研究目前的癌症治疗如何帮助免疫细胞“看到”这些突变。我们将在重要的癌症肺癌和间皮瘤中进行这些研究。