Real-time Imaging of cell cycle progression in melanoma

黑色素瘤是最具侵袭性的皮肤癌，并且具有高度的治疗抗性，其原因知之甚少。在这里，我们假设，在不同肿瘤区域的黑色素瘤细胞的生长能力的差异有助于治疗耐药性。我们将使用一种新的显微系统，使我们能够在真实的时间内可视化完整肿瘤中单个黑色素瘤细胞的分裂。使用这个系统，我们将测试靶向治疗对黑色素瘤细胞生长和存活的影响。

Melanoma is the most aggressive skin cancer and is highly therapy resistant, reasons of which are poorly understood. Here we hypothesise that differences in the growth capacity of melanoma cells in different tumour regions contribute to therapy resistance. We will use a novel microscopic system that allows us to visualise division of individual melanoma cells in intact tumours in real time. Using this system, we will test the effects of targeted therapies on melanoma cell growth and survival.