Reconceptualising neurophysiological biomarkers of schizophrenia: an investigation of the MMN/P3a complex in early psychotic disorders

重新概念化精神分裂症的神经生理学生物标志物：早期精神障碍中 MMN/P3a 复合体的研究

• 批准号: nhmrc : 1039894
• 负责人: Dr Manreena Kaur
• 金额: $ 3.12万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Postgraduate Scholarships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/reconceptualising-neurophysiological-biomarkers-psychotic-disorders/111313
• 关键词: Reconceptualising; neurophysiological; biomarkers; schizophrenia; investigation

I am measuring a brain response to subtle changes in the environment called �mismatch negativity�. MMN indexes fundamental sensory processes that help the brain focus on certain information and ignore other information. MMN is consistently impaired in patients with Schizophrenia and is thought to be a biomarker of this illness. I am assessing MMN in the very early stages of psychosis to determine its specificity and whether it predicts illness trajectory.

我正在测量大脑对环境中微妙变化的反应，称为“失配负性”。MMN索引帮助大脑专注于某些信息而忽略其他信息的基本感觉过程。MMN在精神分裂症患者中持续受损，被认为是这种疾病的生物标志物。我正在评估精神病早期阶段的MMN，以确定其特异性以及是否可以预测疾病轨迹。