Reduced baroreceptor reflex control of heart rate in chronic renal failure

患有肾脏疾病的人更有可能死于心脏病，而不是他们生病的肾脏。其中一个原因是，由于控制心脏的神经回路功能失调，他们的心脏不能对血压的变化做出适当的反应。我们将研究在哪里以及为什么这个回路的组成部分不能对血压的变化做出反应。这将有助于指导新的治疗方法，以减少心脏病的发病率和与肾脏疾病相关的死亡风险。

People with kidney disease are more likely to die of heart disease than their ailing kidneys. One reason is because their hearts do not respond properly to changes in blood pressure, as the nerve circuits controlling the heart become dysfunctional. We will examine where and why components of this circuit are unable to respond to changes in blood pressure. This will help guide new treatments to reduce the incidence of heart disease and risk of death associated with kidney disease.