Environmentally Induced Non-genetic Effects on Ageing and Fitness over Multi-generations and the Evolution of Life-history Trade-offs

环境引起的对多代衰老和健康的非遗传影响以及生活史权衡的演变

• 批准号: FT130100268
• 负责人: Prof Shinichi Nakagawa
• 金额: $ 60.87万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-02-28 至 2019-10-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT130100268
• 关键词: Environmentally; Induced; Non; genetic; Effects

This project will study trade-offs among growth, lifespan and fecundity, and test the following three predictions by employing a short-lived fish model and cutting-edge statistical and computational modelling. First, different dietary conditions not only affect the fitness of the organism, but also that of subsequent generations. Second, different nutritional effects and transgenerational effects on fitness-related traits are underpinned by epigenetic (or non-genetic) modifications. Third, such epigenetic modifications and their inheritance influence the evolution of life-history trade-offs. This project will link the emerging field of epigenetics with evolutionary theory, and reveal mechanisms of transgenerational epigenetic inheritance.

该项目将研究生长、寿命和繁殖力之间的权衡，并通过采用短寿命鱼类模型和最先进的统计和计算模型来检验以下三个预测。首先，不同的饮食条件不仅影响生物体的健康，而且影响后代的健康。第二，不同的营养效应和对健身相关性状的跨代效应是由表观遗传（或非遗传）修饰支撑的。第三，这种表观遗传修饰及其遗传影响了生活史权衡的进化。本项目将把表观遗传学这一新兴领域与进化理论联系起来，揭示跨代表观遗传的遗传机制。