An integrated virtual cell approach towards elucidating the systems pharmacology of antibiotics against Pseudomonas aeruginosa

铜绿假单胞菌是一种在全球范围内引起危及生命的感染的头等大事危险的‘超级细菌’。这项创新的研究将采用多学科方法，通过考虑细胞中的所有基本成分来模拟细菌对抗生素治疗的反应。该项目具有很高的意义，将改变传统抗菌药理学的范式。重要的是，这项提案针对的是一个紧迫而关键的全球卫生问题：抗生素耐药性。

Pseudomonas aeruginosa is a top-priority dangerous ‘superbug’ causing life-threatening infections worldwide. This innovative study will employ a multi-disciplinary approach to model bacterial responses to antibiotic treatments by taking into account all essential components in a cell. This project is of high significance and will shift the paradigm of traditional antimicrobial pharmacology. Importantly, this proposal targets an urgent and critical global health issue: antibiotic resistance.