An oral loading test to predict susceptibility to fluoropyrimidine drug toxicity

预测对氟嘧啶药物毒性敏感性的口服负荷试验

• 批准号: nhmrc : 569611
• 负责人: A/Pr Bruce Charles
• 金额: $ 15.04万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/an-oral-loading-drug-toxicity/96994
• 关键词: oral; loading; test; predict; susceptibility

Side-effects from anticancer drugs can be unpleasant, but may be deadly if a patient's genes are wrong for the drugs. A common chemotherapy drug, fluorouracil, can be very dangerous, but there's no simple way to predict this. We developed a simple test in which a small amount of a natural chemical is swallowed before chemotherapy. The results should allow the doctor to predict if a patient will suffer serious side effects on fluorouracil, so the dose can be reduced, or another drug tried.

抗癌药物的副作用可能令人不快，但如果患者的基因与药物不符，可能是致命的。一种常见的化疗药物氟尿嘧啶可能非常危险，但没有简单的方法来预测这一点。我们开发了一种简单的测试方法，即在化疗前吞服少量的天然化学物质。结果应该可以让医生预测患者是否会遭受氟尿嘧啶的严重副作用，这样就可以减少剂量，或者尝试另一种药物。