Tissue structure and mechanical function relationships of the human temporomandibular lateral capsule-ligament: Investigation of sexual and racial dimorphisms

人类颞下颌外侧囊韧带的组织结构和机械功能关系：性别和种族二态性的调查

• 批准号: 10525626
• 负责人: Cherice Natasha Hill
• 金额: $ 10.77万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-04 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10525626
• 关键词: Adult; Affect; African American population; Appointment; Articulation; Biochemical; Biological Assay; Biology; Biomechanics; Biomedical Engineering; Characteristics; Charge; Chemicals; Chronic; Collagen; Complex; Development; Dislocations; Elements; Environment; Enzyme-Linked Immunosorbent Assay; Etiology; Evaluation; Faculty; Family; Fellowship; Female; Generations; Glycosaminoglycans; Goals; Human; Incidence; Investigation; Joints; Lateral; Ligaments; Literature; Low Prevalence; Mandibular Condyle; Manuscripts; Mechanics; Mentors; Microscopy; Modeling; Molecular; Molecular and Cellular Biology; Morphology; Pain; Pathologic; Pathology; Pathway interactions; Patients; Phase; Population Heterogeneity; Postdoctoral Fellow; Preparation; Prevalence; Property; Protocols documentation; Race; Relaxation; Reporting; Research; Research Personnel; Research Project Grants; Research Proposals; Resource Development; Resources; Risk; Risk Assessment; Risk Estimate; Risk Factors; Sampling; Sex Differences; Stress; Structure; Symptoms; System; Temporal bone structure; Temporomandibular Joint; Temporomandibular Joint Disorders; Testing; Time; Tissues; Training; Translational Research; United States; United States National Institutes of Health; Universities; Woman; Work; Writing; biomechanical test; capsule; caucasian American; chemical property; clinical care; craniofacial; density; dimorphism; experience; high risk; joint destruction; joint loading; male; men; post-doctoral training; programs; racial difference; racial disparity; resilience; responsible research conduct; second harmonic; sex; sex determination; sex disparity; sexual dimorphism; skill acquisition; social; statistics; success; viscoelasticity

Project Summary/Abstract As many as 10 million adults in the United States have temporomandibular disorders (TMDs). Females experience TMDs at higher rates compared to males and African Americans have higher TMD incidence, yet lower prevalence compared to white Americans. Despite these findings, etiological mechanisms contributing to prevalence and incidence disparities by sex and race are largely unknown. Given our recent reports on sexual dimorphisms in incremental tensile stiffness and fixed charge density of the human temporomandibular disc, it is hypothesized that additional sexual dimorphisms may exist in properties of the temporomandibular joint (TMJ). Similar differences are also hypothesized to exist between racial groups, although this possibility has not yet been explored, which may limit research translational confidence across racial groups. The lateral capsule- ligament (LCL) complex, which spans the temporal bone and mandibular condyle, could impact temporomandibular disc derangement (TMDD) risk through a ‘loose ligament’ mechanism affecting joint articulation postulated in prior literature. Furthermore, sex- and race-specific differences in potential risk and resiliency factors may contribute to differential risk of TMDD development and observed TMD prevalence and incidence disparities. Our long-term goal is to enable individualized TMDD risk assessment to increase applicability of generated risk estimates. The objective of this study is to describe sex- and race-specific mechano-chemical LCL complex properties to investigate potential contributions to TMD disparities between sexes and racial groups. The central hypothesis is that TMJ properties observed in females and African Americans will be associated with higher risk of TMDD development compared to those of males and white Americans. The proposed studies will enable the determination of sex- and race-specific differences in potential mechanical and chemical risk factors for TMD development (Aims 1 and 2). This determination will contribute to a better understanding of TMJ properties across diverse populations and is crucial to enabling understanding of TMD incidence and prevalence disparities. Finite element models will also be used to investigate how differences between sexes and racial groups impact the temporomandibular loading environment, which will be developed, refined, and interpreted during the independent phase (Aim 3). This proposal aims to further development of scientific expertise and skill acquisition in temporomandibular and craniofacial biomechanics, with a plan to transition from mentored post-doctoral fellowship to independent faculty. NIH T32 training and professional development resources, joint resources and network of the Clemson- MUSC Bioengineering program, and the Clemson University Pathways Mentoring Program provide an ideal inter-disciplinary training environment to prepare for and transition to independence following the postdoctoral fellowship period.

项目总结/文摘