Tissue structure and mechanical function relationships of the human temporomandibular lateral capsule-ligament: Investigation of sexual and racial dimorphisms

项目摘要/摘要 在美国，多达1000万成年人患有颞下颌关节紊乱病(TMD)。女性 与男性相比，TMD的发病率更高，非裔美国人的TMD发病率也更高 与美国白人相比，患病率更低。尽管有这些发现，但致病机制有助于 按性别和种族划分的患病率和发病率差异在很大程度上是未知的。鉴于我们最近关于性行为的报道 人颞下颌关节盘增量拉伸刚度和固定电荷密度的二形性 假设在颞颌关节(TMJ)的特性中可能存在附加性二型性。 类似的差异也被假设存在于种族群体之间，尽管这种可能性还没有 这可能会限制不同种族群体对研究翻译的信心。侧囊- 横跨颞骨和下颌骨的韧带(LCL)复合体可能会影响 影响关节的“韧带松动”机制导致的颞下颌关节盘排列紊乱(TMDD)风险 在以前的文献中假定的发音。此外，不同性别和种族的潜在风险和 复原力因素可能有助于区分TMDD的发展风险和观察到的TMD流行率和 发病率差异。我们的长期目标是实现个性化的TMDD风险评估 生成的风险估计的适用性。这项研究的目的是描述性别和种族的具体情况 机械力-化学LCL复合体性质研究对TMD差异的潜在贡献 性别和种族群体之间的差异。中心假设是在女性和 与男性相比，非裔美国人患TMDD的风险更高 美国白人。拟议的研究将能够确定性别和种族的差异 TMD发展的潜在机械和化学风险因素(目标1和2)。这一决心将 有助于更好地了解不同人群的TMJ属性，并对实现 对TMD发病率和患病率差异的了解。有限元模型还将用于 研究性别和种族差异对颞下颌关节负荷的影响 环境，将在独立阶段进行开发、改进和解释(目标3)。这 提案旨在进一步发展颞颌和下颌骨的科学专长和技能获得 颅面生物力学，计划从指导博士后研究员过渡到独立博士后 教职员工。NIH T32培训和专业发展资源、联合资源和克莱姆森网络- MUSC生物工程计划和克莱姆森大学路径指导计划提供了一个理想的 跨学科培训环境，为博士后毕业后的独立做准备和过渡 团契期间。

Project Summary/Abstract As many as 10 million adults in the United States have temporomandibular disorders (TMDs). Females experience TMDs at higher rates compared to males and African Americans have higher TMD incidence, yet lower prevalence compared to white Americans. Despite these findings, etiological mechanisms contributing to prevalence and incidence disparities by sex and race are largely unknown. Given our recent reports on sexual dimorphisms in incremental tensile stiffness and fixed charge density of the human temporomandibular disc, it is hypothesized that additional sexual dimorphisms may exist in properties of the temporomandibular joint (TMJ). Similar differences are also hypothesized to exist between racial groups, although this possibility has not yet been explored, which may limit research translational confidence across racial groups. The lateral capsule- ligament (LCL) complex, which spans the temporal bone and mandibular condyle, could impact temporomandibular disc derangement (TMDD) risk through a ‘loose ligament’ mechanism affecting joint articulation postulated in prior literature. Furthermore, sex- and race-specific differences in potential risk and resiliency factors may contribute to differential risk of TMDD development and observed TMD prevalence and incidence disparities. Our long-term goal is to enable individualized TMDD risk assessment to increase applicability of generated risk estimates. The objective of this study is to describe sex- and race-specific mechano-chemical LCL complex properties to investigate potential contributions to TMD disparities between sexes and racial groups. The central hypothesis is that TMJ properties observed in females and African Americans will be associated with higher risk of TMDD development compared to those of males and white Americans. The proposed studies will enable the determination of sex- and race-specific differences in potential mechanical and chemical risk factors for TMD development (Aims 1 and 2). This determination will contribute to a better understanding of TMJ properties across diverse populations and is crucial to enabling understanding of TMD incidence and prevalence disparities. Finite element models will also be used to investigate how differences between sexes and racial groups impact the temporomandibular loading environment, which will be developed, refined, and interpreted during the independent phase (Aim 3). This proposal aims to further development of scientific expertise and skill acquisition in temporomandibular and craniofacial biomechanics, with a plan to transition from mentored post-doctoral fellowship to independent faculty. NIH T32 training and professional development resources, joint resources and network of the Clemson- MUSC Bioengineering program, and the Clemson University Pathways Mentoring Program provide an ideal inter-disciplinary training environment to prepare for and transition to independence following the postdoctoral fellowship period.