Analysing the immune response and optimising the effectiveness of Mesothelin CAR T-cell therapy in cancer.

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Chimeric Antigen Receptor (CAR) T-cells have engineered receptors attached to patient immune cells. They target cancer with less risk of damage to healthy cells. Our laboratory manufactures CAR T-cells targeting a tumour marker- mesothelin, found on pancreatic and other cancers. I plan to test these CAR T-cells in vitro and in mice followed by enrolling cancer patients in a clinical trial of CAR T-cells. My aim is to monitor safety, efficacy and help improve patient survival and quality of life.