Analysis of apoptotic pathways to develop better therapies for unresponsive cancers.

分析细胞凋亡途径，为无反应的癌症开发更好的疗法。

• 批准号: nhmrc : 541930
• 负责人: A/Pr Christine Hawkins
• 金额: $ 8.72万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/analysis-apoptotic-pathways-unresponsive-cancers/115866
• 关键词: Analysis; apoptotic; pathways; develop; better

Tight control of the balance between cellular survival and death is important for normal development and to avoid numerous diseases. Inappropriate survival of precancerous cells can contribute to oncogenesis. Anti-cancer therapies act by inducing a cellular self-destruct program in tumour cells, and blocks in pathways controlling this process can lead to resistance to anti-cancer treatments. Defining cell death pathways will enable the development of better therapies for incurable cancers.

严格控制细胞存活和死亡之间的平衡对于正常发育和避免许多疾病是重要的。癌前细胞的不适当存活可促成肿瘤发生。抗癌疗法通过诱导肿瘤细胞中的细胞自毁程序起作用，并且控制这一过程的通路中的阻断可导致对抗癌治疗的抗性。确定细胞死亡途径将有助于为无法治愈的癌症开发更好的疗法。