Viral caspase inhibitors

病毒半胱天冬酶抑制剂

• 批准号: nhmrc : 602525
• 负责人: A/Pr Christine Hawkins
• 金额: $ 39.1万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/viral-caspase-inhibitors/100393
• 关键词: Viral; caspase; inhibitors

The balance between cellular survival and death must be tightly regulated. Cells respond to viral infection by self-destructing, thus limiting viral spread to other cells. Viruses have evolved ways to subvert this defensive cell suicide. This project will define and characterise viral factors that maintain host cell survival during infection. These may be targets for the development of new anti-viral therapies and vaccines.

细胞生存和死亡之间的平衡必须受到严格调节。细胞通过自毁来应对病毒感染，从而限制病毒传播到其他细胞。病毒已经进化出了颠覆这种防御性细胞自杀的方法。该项目将定义和表征感染期间维持宿主细胞存活的病毒因子。这些可能是开发新的抗病毒疗法和疫苗的目标。