Analysis of the role of Polycomb genes in normal and diseased breast stem cells

Polycomb 基因在正常和患病乳腺干细胞中的作用分析

• 批准号: nhmrc : 575577
• 负责人: Dr Ewa Michalak
• 金额: $ 24.19万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/analysis-role-polycomb-stem-cells/116231
• 关键词: Analysis; role; Polycomb; genes; normal

In Australia, 1 in 8 women will be diagnosed with breast cancer. Many will receive chemotherapy that will apparently eliminate the cancer. However, in approximately 1 in 3 of these women, cancer will recur. This is thought to be due to the presence of chemotherapy-resistant breast cancer stem cells. This project will study the parallels between the role of Polycomb genes in normal mammary stem cell maintenance and their role in breast cancer, in order to improve treatment and cure rates.

在澳大利亚，每8名女性中就有1名被诊断出患有乳腺癌。许多人将接受化疗，这显然将消除癌症。然而，在这些女性中，大约有三分之一的人会复发癌症。这被认为是由于化疗耐药乳腺癌干细胞的存在。该项目将研究Polycomb基因在正常乳腺干细胞维持中的作用与其在乳腺癌中的作用之间的相似之处，以提高治疗和治愈率。