System biology approaches to uncovering non-coding RNAs' roles in characterising cancer subtypes

系统生物学方法揭示非编码 RNA 在表征癌症亚型中的作用

• 批准号: nhmrc : GNT1123042
• 负责人: Dr Thuc Le
• 金额: $ 31.88万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/biology-approaches-uncovering-cancer-subtypes/1347319
• 关键词: System; biology; approaches; uncovering; non

I aim to investigate non-coding RNAs (ncRNAs)’ roles in cancer development, and how they characterise cancer subtypes. The outcomes of the proposed research are twofold: computational methods to stratify tumor subtypes and computational methods to identify groups of ncRNAs acting as drivers for each cancer subtype. The research outcomes will enable prediction of new patients’ cancer subtypes and contribute to the design of efficient treatment therapies.

我的目标是研究非编码RNA（ncRNA）在癌症发展中的作用，以及它们如何识别癌症亚型。拟议研究的结果是双重的：对肿瘤亚型进行分层的计算方法和识别作为每种癌症亚型驱动因素的ncRNA组的计算方法。研究结果将能够预测新患者的癌症亚型，并有助于设计有效的治疗方法。