The control of group A streptococcal disease in endemic populations

A 组链球菌疾病，包括风湿性心脏病，是全球（主要是发展中国家）疾病的主要原因。该提案旨在调查如何最好地控制这些疾病。它的重点是 1) 一种利用超声波在早期阶段检测风湿性心脏病的新方法，2) 每年使用单一药物一次，通过控制整个社区的疥疮感染来阻止链球菌皮肤溃疡，3) 开发一种适用于世界所有地区的新疫苗。

Group A streptococcal diseases, including rheumatic heart disease, are major causes of illness globally, mostly in developing countries. This proposal is an investigation into how best to tackle control these diseases. It focuses on 1) a novel way to detect rheumatic heart disease in its earliest phases using ultrasound, 2) using a single drug once per year to stop streptococcal skin sores by controlling scabies infestation in whole communities and 3) developing a new vaccine that is applicable across all regions of the world.