The early life origins of impaired testicular function: A prospective cohort study

睾丸功能受损的早期生命起源：一项前瞻性队列研究

• 批准号: nhmrc : 634457
• 负责人: Dr Deborah Sloboda
• 金额: $ 41.56万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/early-life-origins-cohort-study/94436
• 关键词: early; life; origins; impaired; testicular

There is a widespread public perception that sperm counts are diminishing. This theory can only be tested by using a representative sample of young men, rather than biased populations (such as men presenting as sperm donors). We have the unique opportunity to test this theory, and to determine any early life events which may lead to reduced sperm counts, such as being growth restricted at birth, exposed to high levels of maternal oestrogens or smoking or being overweight in adolescence.

公众普遍认为精子数量正在减少。这一理论只能通过使用具有代表性的年轻男性样本来检验，而不是使用有偏见的人群（例如作为精子捐赠者的男性）。我们有独特的机会来检验这一理论，并确定任何可能导致精子数量减少的早期生活事件，例如出生时生长受限、暴露于高水平的母体雌激素或吸烟或青春期超重。