The effect of alteration of glucose use on brain function

改变葡萄糖使用对大脑功能的影响

• 批准号: nhmrc : 107201
• 负责人: Prof Caroline Rae
• 金额: $ 8.78万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effect-alteration-glucose-brain-function/81773
• 关键词: effect; alteration; glucose; use; brain

Glucose has long been accepted as the mandatory fuel for the brain although it is not fully understood why this is so. Impairment of the glucose supply to the brain results in impairment in brain functions, coma and ultimately death. As a result the body possesses rigid regulatory systems to maintain blood glucose levels within set limits. In certain conditions where blood glucose levels frequently drop below normal, the brain compensates by increasing the uptake of glucose into the brain thus keeping the glucose supply normal despite lower than normal blood glucose concentrations. In these conditions, which include diabetic hypoglycaemia unawareness, anorexia and starvation, the normal hormonal systems warning of low blood glucose are bypassed. However, despite normal glucose supply to the brain, the performance of the brain is still adversely affected. The electrical activity of the brain changes, reaction times slow, and vigilance is decreased. This implies that, despite the brain having a normal supply of glucose, the glucose is being used differently and that these differences affect the functional performance of the brain. The AIMS of this study are to determine: 1. How does the use of glucose vary in the hypoglycaemia unawareness state? 2. How do these variations effect the performance of the brain? The SIGNIFICANCE of this work lies in 1. Increasing our understanding of the role of glucose in the brain, 2. Increasing our understanding of how the brain works, and, 3. Increasing our understanding of why cognitive impairment occurs in disorders such as diabetes, anorexia and starvation and whether this impairment is reversible. 4. Developing application of a relatively new technique, functional magnetic resonance spectroscopy, for use study of biochemical and cognitive brain disorders.

长期以来，葡萄糖一直被认为是大脑的必需燃料，尽管还没有完全理解为什么会这样。对大脑的葡萄糖供应的损害导致脑功能的损害、昏迷和最终死亡。因此，身体拥有严格的调节系统，以将血糖水平维持在设定的限度内。在血糖水平经常低于正常的某些情况下，大脑通过增加葡萄糖摄入大脑来补偿，从而保持葡萄糖供应正常，尽管低于正常的血糖浓度。在这些情况下，包括糖尿病低血糖无意识，厌食和饥饿，正常的激素系统警告低血糖被绕过。然而，尽管正常的葡萄糖供应到大脑，大脑的性能仍然受到不利影响。大脑的电活动发生变化，反应时间变慢，警惕性降低。这意味着，尽管大脑有正常的葡萄糖供应，但葡萄糖的使用方式不同，这些差异会影响大脑的功能表现。本研究的目的是确定：1。在低血糖无意识状态下，葡萄糖的使用如何变化？2.这些变化如何影响大脑的表现？这项工作的意义在于1。增加我们对葡萄糖在大脑中作用的理解，2。增加我们对大脑如何工作的了解，3。增加我们对糖尿病、厌食症和饥饿等疾病中发生认知障碍的原因以及这种障碍是否可逆的理解。4.开发一种相对较新的技术，功能性磁共振波谱，用于研究生化和认知脑障碍。