The effects of intestinal inflammation on the currents and channels of identified enteric neurons

肠道炎症对已识别肠神经元电流和通道的影响

• 批准号: nhmrc : 400020
• 负责人: A/Pr Kulmira Nurgali
• 金额: $ 31.76万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effects-intestinal-inflammation-enteric-neurons/99788
• 关键词: effects; intestinal; inflammation; currents; channels

Intestinal inflammation, in gastroenteritis, Crohn's disease, ileitis or colitis, has effects on the motility (movement) of the gastrointestinal and on secretion within it. The symptoms that are recognised are poor digestion, crampy pains and diarrhoea. The symptoms often continue after the inflammation has subsided. The major disease entity that can develop after inflammation is the irritable bowel syndrome (IBS). IBS is associated with persistent disorders of bowel motility. The symptoms are triggered by changes in the properties of enteric neurons, many of which become hyperexcitable. Enteric neurons are part of the nervous system within the gut wall. However, the neurons that have changed properties after inflammation have not been identified, and the mechanisms of change are not known. This work is designed to determine the molecular basis of the changes in neuron excitability that lead to hyperexcitability. Identification of the molecules whose properties are changed will permit those molecules to be targeted in the design of compounds to treat the abnormalities of intestinal physiology that follow inflammation.

胃肠炎、克罗恩病、回肠炎或结肠炎中的肠道炎症会影响胃肠道的蠕动（运动）及其内的分泌。公认的症状是消化不良、痉挛性疼痛和腹泻。炎症消退后，症状通常会持续。炎症后可能发生的主要疾病是肠易激综合征（IBS）。 IBS 与持续的肠蠕动障碍有关。这些症状是由肠神经元特性的变化引发的，其中许多神经元变得过度兴奋。肠神经元是肠壁内神经系统的一部分。然而，炎症后性质发生改变的神经元尚未被识别，并且改变的机制尚不清楚。这项工作旨在确定导致过度兴奋的神经元兴奋性变化的分子基础。鉴定出性质发生改变的分子将允许在设计化合物时以这些分子为目标，以治疗炎症后肠道生理学的异常。