The role of voltage-gated Na+ and Ca2+ channels in post-inflammatory hyperexcitability of enteric neurons

电压门控Na和Ca2通道在肠神经元炎症后过度兴奋中的作用

• 批准号: nhmrc : 566502
• 负责人: A/Pr Kulmira Nurgali
• 金额: $ 34.67万
• 依托单位: Victoria University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-voltage-gated-enteric-neurons/99996
• 关键词: role; voltage; gated; Na+; Ca2+

Gastrointestinal inflammation causes changes in neurons that control gut functions (motility and secretion). These changes in neuronal properties lead to the development of post-inflammatory motility disorders. This will be the first detailed study of neuronal ion channels that are changed after inflammation in the gut. Our study will open the way to the development of therapeutic agents to treat post-inflammatory IBS and other conditions that involve disorders of motility.

胃肠道炎症导致控制肠道功能（运动和分泌）的神经元发生变化。神经元特性的这些变化导致炎症后运动障碍的发展。这将是第一次详细研究肠道炎症后神经元离子通道的变化。我们的研究将为开发治疗炎症后IBS和其他涉及运动障碍的疾病的治疗药物开辟道路。