The effects of phencyclidine on the NMDA receptor-neuregulin1 signalling complex: implications for schizophrenia
The effects of phencyclidine on the NMDA receptor-neuregulin1 signalling complex: implications for schizophrenia
苯环己哌啶对 NMDA 受体-神经调节蛋白 1 信号复合物的影响：对精神分裂症的影响
批准号：
nhmrc : 573426
负责人：
A/Pr Kelly Newell
金额：
$28.93万
依托单位：
依托单位国家：
澳大利亚
项目类别：
NHMRC Project Grants
财政年份：
2009
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2009-01-01 至 2012-12-31
中文摘要
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英文摘要
Phencyclidine is the best known pharmacological agent that can induce schizophrenia-like symptoms in humans and animals. Recent research has strongly suggested that neuregulin1 and ErbB4 signalling are involved in schizophrenia pathology. This study will be the first to determine whether neuregulin1 is altered by phencyclidine, which will further our knowledge by re-evaluating the causal role of neuregulin1 in schizophrenia.
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