The function of gametogenenin in male fertility and embryogenesis

配子生成素在雄性生育力和胚胎发生中的作用

• 批准号: nhmrc : 490917
• 负责人: Prof Keith Jones
• 金额: $ 35.85万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/function-gametogenenin-male-fertility-embryogenesis/99260
• 关键词: function; gametogenenin; male; fertility; embryogenesis

We have identified gametogenetin as novel protein involved in sperm production and in the very earliest stages of embryo survival. It is found within the sperm tail where it binds to cysteine-rich secretory protein 2. The aim of this project is to further refine the biochemistry of GGN using a combination of binding studies, expression analyses and the characterization of two unique mouse models. This project has direct relevance to the causes of human infertility and contraceptive development.

我们已经确定配子体遗传蛋白是一种新的蛋白质，参与精子的产生和胚胎生存的最早阶段。它存在于精子尾部，与富含半胱氨酸的分泌蛋白2结合。该项目的目的是通过结合结合研究、表达分析和两种独特小鼠模型的表征，进一步完善GGN的生物化学。该项目与人类不育的原因和避孕措施的发展直接相关。