The impact of influenza A virus PB1-F2 protein on host immunity and the potential for therapeutic targeting

甲型流感病毒PB1-F2蛋白对宿主免疫的影响和治疗靶向的潜力

• 批准号: nhmrc : 566780
• 负责人: Dr Julie Mcauley
• 金额: $ 21.14万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/impact-influenza-virus-therapeutic-targeting/81376
• 关键词: impact; influenza; virus; PB1; F2

The 1918 influenza virus pandemic resulted in 50 million deaths globally and there is potential for new pandemics, such as the predicted H5N1 Bird Flu . Exact causes of such devastating lethality are not fully identified. Newly discovered influenza A virus (IAV) PB1-F2 protein is present in nearly all highly pathogenic IAVs and promotes virus virulence. This study will further examine the way in which PB1-F2 impacts the host, revealing potential therapeutic targets to lessen disease burden.

1918年的流感病毒大流行导致全球5000万人死亡，并有可能出现新的大流行，如预测的H5 N1禽流感。造成这种毁灭性杀伤力的确切原因尚未完全查明。新发现的A型流感病毒（IAV）PB 1-F2蛋白存在于几乎所有高致病性IAV中，并促进病毒毒力。这项研究将进一步研究PB 1-F2影响宿主的方式，揭示潜在的治疗靶点，以减轻疾病负担。