The Impact of Wnt Signaling on Spermatogenesis

Wnt 信号传导对精子发生的影响

• 批准号: nhmrc : 1011340
• 负责人: A/Pr Helen Abud
• 金额: $ 38.56万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/impact-wnt-signaling-spermatogenesis/109576
• 关键词: Impact; Wnt; Signaling; Spermatogenesis

Male fertility requires sufficient production of healthy sperm in the testis. This project builds on our discovery that testicular cells communicate via the wnt family of proteins during sperm development, and that interruption of their activities reduces fertility in mice. We propose to use mouse models to study the precise steps in sperm production affected by Wnt signalling and how it works.

男性生育力需要睾丸中产生足够的健康精子。这个项目建立在我们发现睾丸细胞在精子发育过程中通过wnt蛋白家族进行交流的基础上，而中断它们的活动会降低小鼠的生育能力。我们建议使用小鼠模型来研究受Wnt信号影响的精子产生的精确步骤及其工作原理。