Building an intestine: manipulating regeneration of the epithelium

构建肠道：操纵上皮再生

• 批准号: nhmrc : 1011187
• 负责人: A/Pr Helen Abud
• 金额: $ 40.64万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/building-an-intestine-regeneration-epithelium/109559
• 关键词: Building; intestine; manipulating; regeneration; epithelium

Diseases, infections and pathologies are common clinical problems of the intestinal lining in both infants and adults. Individuals with these conditions can experience nutritional problems and severe cases result in death. The intestinal lining is generated from a small population of stem cells. In this study we use of a mouse model where the stem cells are marked and will examine what factors regulate stem cells in the intestine with the aim of facilitating intestinal tissue regeneration.

疾病、感染和病理学是婴儿和成人肠道衬里的常见临床问题。患有这些疾病的人可能会出现营养问题，严重者会导致死亡。肠内膜是由一小群干细胞产生的。在这项研究中，我们使用了一个小鼠模型，其中干细胞被标记，并将检查哪些因素调节肠道中的干细胞，目的是促进肠道组织再生。