The influence of glucocorticoid hormones in T cell development and function

糖皮质激素对T细胞发育和功能的影响

• 批准号: nhmrc : 194253
• 负责人: A/Pr Timothy Cole
• 金额: $ 27.14万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/influence-glucocorticoid-hormones-development-function/81479
• 关键词: influence; glucocorticoid; hormones; cell; development

The defence of the body to disease is a very complex process involving multiple interactions between subsets of white cells, in particular lymphocytes. This immune system, however, does not act in isolation but is subject to constant regulation by a variety of other cells and soluble factors. Particularly important in this regard is the impact of glucocorticoids which are normally associated with stress conditions. These steroids have been proposed to act at several levels in the immune system, usually causing suppression but they can also modify in a positive sense. Defining the targets of glucocorticoids and their precise functional impact will thus have very important implications for not only understanding the regulation of the immune response but also in the clinic. This project will make use of mice which have had the receptor for glucocorticoids genetically deleted. Focussing on T cells (the most important cells of the immune system) these mice will be examined in detail for alterations in the development of T lymphocytes and their function in defending the body against virus and tumours and their involvement in self destruction (autoimmune) diseases including multiple sclerosis.

身体对疾病的防御是一个非常复杂的过程，涉及到白细胞亚群之间的多个相互作用，特别是淋巴细胞。然而，这种免疫系统并不是孤立地发挥作用，而是受到各种其他细胞和可溶性因子的持续调节。在这方面特别重要的是糖皮质激素的影响，这通常与应激条件有关。这些类固醇被认为在免疫系统的几个层面上起作用，通常会导致抑制，但它们也可以在积极的意义上进行调整。因此，明确糖皮质激素的靶点及其确切的功能影响，不仅对于理解免疫反应的调节，而且对于临床都具有非常重要的意义。该项目将利用基因缺失了糖皮质激素受体的小鼠。以T细胞(免疫系统最重要的细胞)为重点，这些小鼠将被详细检查T淋巴细胞发育的变化及其防御病毒和肿瘤的功能，以及它们参与包括多发性硬化症在内的自我破坏(自身免疫)疾病的情况。