A Biobehavioral Intervention to Reduce Adverse Outcomes in Young Adult Testicular Cancer Survivors
减少年轻成年睾丸癌幸存者不良后果的生物行为干预
基本信息
- 批准号:10736501
- 负责人:
- 金额:$ 67.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-07-08 至 2028-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdverse effectsAftercareAgeBehavior TherapyBehavioralBiological FactorsBiological MarkersBiological SciencesCaliforniaCancer PatientCancer SurvivorChronic DiseaseClinicCohort StudiesComprehensive Cancer CenterConfusionCountyDNA MethylationDiseaseDistressEconomicsEducationEmotionalEmotionsEpigenetic ProcessFamilyGeneral PopulationGenesGlucocorticoid ReceptorGoalsHormonesHydrocortisoneImpairmentIndividualInflammationInformal Social ControlInterleukin-6InterruptionInterventionLate EffectsLifeLongevityMalignant NeoplasmsMalignant neoplasm of testisMeasuresMediationMedicalMemorial Sloan-Kettering Cancer CenterMental DepressionMorbidity - disease rateNR3C1 geneOncologyOrangesOutcomeParticipantPatternPediatric HospitalsPopulationPositioning AttributePrevalenceProductionPsychological FactorsRaceRandom AllocationRandomizedReceptor GeneReproductive HealthResearchResolutionRiskSalivarySecond Primary CancersSexualityStressSurvivorsTestingTimeTreatment Side EffectsUrologic OncologyValue of LifeVideoconferencingWorkadverse outcomeanakinraanxiety symptomsbiobehaviorcancer diagnosiscancer therapycareercomparativedepressive symptomsdesigneffective interventionefficacy evaluationemerging adulthoodemotion regulationexperiencefollow-upimprovedmood regulationneoplasm registrynovelpilot testpost interventionprimary outcomepsychologicpsychological distresspsychosocialpsychosocial adjustmentrecruitresponsesecondary outcomeserotonin transporterside effectskillsstress reactivitysuccesssurvivorshipsystemic inflammatory responsetherapy designvideo chatyoung adult
项目摘要
Project Abstract
Testicular cancer diagnosis and treatment, especially given its threat to sexuality and reproductive health,
can be distressing in the formative period of young adulthood. Cohort studies reveal the prevalence of
depressive symptoms in testicular cancer exceeds the general population. In fact, the majority of young adult
cancer survivors will experience impairing, distressing, and modifiable physical, behavioral, and psychosocial
adverse outcomes that persist long after the completion of primary medical treatment. These include
psychological distress, impairment in the navigation and pursuit of life goals, persistent side effects, elevated
risk of secondary malignancies and chronic illness, and biobehavioral burden (e.g., enhanced inflammation,
dysregulated stress hormones) which influence morbidity and disease-related vulnerabilities. However, few
targeted, effective interventions exist to assist young survivors in re-negotiating life goals and regulating
cancer-related emotions and none focus on reducing the burden of morbidity via biobehavioral mechanisms.
Young or “emerging” adulthood is a period marked by goal attainment. Chronic illness experienced as “off
time” in the lifespan interrupts goal pursuits and threatens valued life directions. As young adults return to goal
pursuits, re-entry to post-cancer life can be a critical point in the survivorship trajectory. Behavioral intervention
at this time is well positioned to confer longer-term impact. Emergent from our group’s preliminary research, we
developed and pilot-tested Goal-focused Emotion-Regulation Therapy (GET) as a novel behavioral
intervention to enhance self-regulation through improved goal navigation skills, improved sense of purpose,
and better ability to regulate emotional responses in young adults with testicular cancer. GET is a promising
candidate intervention to address the mechanisms likely complicating the resolution of cancer-related burden.
Responsive the need for feasible, effective, and scalable interventions, we will randomly allocate 300
young adult (ages 18-39) testicular cancer patients to 6 sessions of GET or ISL (individual supportive
listening), and evaluate primary and secondary outcomes at baseline, post-treatment, 3-month follow-up, and
6-months follow-up. We predict that GET will be associated with superior distress outcomes and comparatively
greater reductions in adverse biobehavioral indicators (dysregulated diurnal stress hormones, elevated
inflammation), and these advantages will be maintained at three- and six-months following intervention. The
intervention will be delivered via video conferencing to enhance access. An exploratory aim focuses on
potential epigenetic vulnerabilities, to understand how environmental influences (via DNA methylation) on
genes implicated in stress and mood regulation are related to cancer adjustment and intervention response.
This study capitalizes on the study team’s unique expertise in biobehavioral oncology and salivary
bioscience to test a novel behavioral intervention for young adult survivors. It has potential to understand how
to alter proximal behavioral, biological, and psychological factors that underscore long term adverse effects.
项目摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Michael A Hoyt其他文献
and relationships to approach and avoidance coping to health and health
以及与接近和回避应对健康和健康的关系
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
Katie Darabos;M. Mazza;Jennifer somers;V. song;Michael A Hoyt - 通讯作者:
Michael A Hoyt
Association Between Clinical, Demographic Factors, and Substance Use Among Young Adult Survivors of Childhood Cancer
儿童癌症年轻幸存者的临床、人口统计因素和药物使用之间的关联
- DOI:
10.1158/1055-9965.epi-23-0360 - 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Yoonji Kim;Jimi Huh;Kimberly A Miller;Anamara Ritt;Michael A Hoyt;Joel Milam - 通讯作者:
Joel Milam
Michael A Hoyt的其他文献
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{{ truncateString('Michael A Hoyt', 18)}}的其他基金
Caregiving for Young Adults with Cancer in Latino Families: Understanding Healthcare Engagement and Family Wellbeing
护理拉丁裔家庭中患有癌症的年轻人:了解医疗保健参与和家庭福祉
- 批准号:
10463711 - 财政年份:2021
- 资助金额:
$ 67.3万 - 项目类别:
Caregiving for Young Adults with Cancer in Latino Families: Understanding Healthcare Engagement and Family Wellbeing
护理拉丁裔家庭中患有癌症的年轻人:了解医疗保健参与和家庭福祉
- 批准号:
10269806 - 财政年份:2021
- 资助金额:
$ 67.3万 - 项目类别:
Emotion-Regulation, Inflammatory Processes, and Depression in Prostate Cancer Sur
前列腺癌的情绪调节、炎症过程和抑郁
- 批准号:
8630215 - 财政年份:2014
- 资助金额:
$ 67.3万 - 项目类别:
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